期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 18, 期 12, 页码 3745-3752出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201103066
关键词
core-shell nanoparticles; fluorescence; imaging agents; magnetic properties; yolk-shell nanocapsules
资金
- National Natural Science Foundation of China [21173038, 20703009]
- Fundamental Research Funds for the Central University [10 JCXK006]
- Specialized Research Fund for the Doctoral Program of Higher Education of China [20070200021]
- Science and Technology Development Planning of Jilin Province [20100929, 20100320]
The selected-control preparation of uniform coreshell and yolkshell architectures, which combine the multiple functions of a superparamagnetic iron oxide (SPIO) core and europium-doped yttrium oxide (Y2O3:Eu) shell in a single material with tunable fluorescence and magnetic properties, has been successfully achieved by controlling the heat-treatment conditions. Furthermore, the shell thickness and interior cavity of SPIO@Y2O3:Eu coreshell and yolkshell nanostructures can be precisely tuned. Importantly, as-prepared SPIO@Y2O3:Eu yolkshell nanocapsules (NCs) modified with amino groups as cancer-cell fluorescence imaging agents are also demonstrated. To the best of our knowledge, this is the first report on the selected-control fabrication of uniform SPIO@Y2O3:Eu coreshell nanoparticles and yolkshell NCs. The combined magnetic manipulation and optical monitoring of magneticfluorescent SPIO@Y2O3:Eu yolkshell NCs will open up many exciting opportunities in dual imaging for targeted delivery and thermal therapy.
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