期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 19, 期 5, 页码 1666-1671出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201203104
关键词
cyclohexanol; domino reactions; Henry reaction; Michael addition; organocatalysis
资金
- Welch Foundation [AX-1573]
A highly diastereoselective (d.r. >99:1) and enantioselective (ee value up to 96?%) synthesis of trisubstituted cyclohexanols was achieved by using a one-pot sequential organocatalysis that involved a quinidine thiourea-catalyzed tandem HenryMichael reaction between nitromethane and 7-oxo-hept-5-en-1-als followed by a tetramethyl guanidine (TMG)-catalyzed tandem retro-HenryHenry reaction on the reaction products of the tandem HenryMichael reaction. Through a mechanistic study, it has also been demonstrated that similar results may also be achieved with this one-pot sequential organocatalysis by using the racemic Henry product as the substrate.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据