期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 18, 期 46, 页码 14671-14679出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201202064
关键词
biological activity; carbohydrates; cell study; click chemistry; photodynamic therapy; porphyrinoids
资金
- School of Chemistry (TCD)
- Health Research Board [TRA/2007/11]
- Science Foundation Ireland [SFI P.I. 09/IN.1/B2650]
- Fundacao da Ciencia e Tecnologia [SFRH/BD/62364/2009]
- IRCSET EMBARK Initiative
- Fundação para a Ciência e a Tecnologia [SFRH/BD/62364/2009] Funding Source: FCT
- Health Research Board (HRB) [TRA-2007-11] Funding Source: Health Research Board (HRB)
A library of glycosylated porphyrins (glycoporphyrins) was prepared and the compounds were evaluated for their photodynamic therapy (PDT) activity against the oesophageal squamous-cell carcinoma cell line OE21 in vitro. A synthetic methodology was developed to allow incorporation of biologically active carbohydrates, including the histo-blood-group antigen trisaccharide Lewis(X), onto the porphyrin backbone. The effect of the carbohydrate group and substitution pattern on the PDT activity, cell uptake and subcellular localisation of the glycoporphyrin compounds is reported.
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