期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 17, 期 16, 页码 4619-4625出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201002815
关键词
chitosan; composites; cytotoxicity; drug delivery; polyoxometalates
资金
- Swiss National Science Foundation (SNSF) [PP002-114711/1]
- University of Zurich
- Center for Microscopy and Image Analysis (ZMB), University of Zurich
- Electron Microscopy ETH Zurich (EMEZ)
- University of Padova [PRAT CPDA084893/08]
Chitosan and its derivates continue to attract considerable research interest as effective drug carriers with good biocompatibility and high cellular uptake rates. We used these versatile features to tap the considerable biomedical potential of polyoxometalates (POMs) through their encapsulation into a carboxymethyl chitosan (CMC) matrix. The nanocapsules were prepared by ionic gelification with Ca2+; their size distribution ranges from 60 to 150 nm. Because [Co-4(H2O)(2)(PW9O34)(2)](10-) is well known for its manifold properties, such as antiviral activity, it was selected as a model POM. The resulting composites were characterised with a wide range of analytical methods, which pointed to quantitative encapsulation of intact POMs within the CMC matrix. We studied the biocompatibility of the POM/CMC nanocomposites on HeLa cells through MTT and proliferation assays. Even after prolonged incubation times at high concentrations, the composites did not display cytotoxicity, thereby drastically reducing the side effects of the pristine POMs. This opens up new avenues for designing novel inorganic drug prototypes from bioactive POMs.
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