期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 17, 期 7, 页码 2211-2214出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201001663
关键词
DNA; gold; mercury; nanowires; surface-enhanced Raman scattering
资金
- NRF through NRL [20090083138]
- SRC [20100001484]
- Nano RD program [20090083221]
- MEST, Korea [2009K000468]
- Ministry of Knowledge Economy
We report an ultrasensitive and selective single nanowire-on-film (SNOF) surface-enhanced resonance Raman scattering (SERRS) sensor for Hg2+ detection based on structure-switching double stranded DNAs (dsDNAs). Binding of Hg2+ induces conformational changes of the dsDNAs and let a Raman reporter get close to the SNOF structure, thereby turning on SERRS signal. The well-defined SNOF structure provides a detection limit of 100 pm with improved accuracy in Hg2+ detection. This sensor is stable over a considerable amount of time and reusable after simple treatment. Since this SNOF sensor is composed of a single Au NW on a film, development of a multiplex sensor would be possible by employing NWs modified by multiple kinds of aptamers.
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