期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 17, 期 6, 页码 1966-1971出版社
WILEY-BLACKWELL
DOI: 10.1002/chem.201002634
关键词
antitumor agents; dendrimers; drug delivery; host-guest systems; metallaprisms
资金
- Swiss National Science Foundation [200020-129501]
The self-assembly of 2,4,6-tris(pyridin-4-yl)-1,3,5-triazine (tpt) triangular panels with p-cymene ruthenium building blocks and 5,8-dioxido-1,4-naphthoquinonato (donq) bridges, in the presence of pyrenyl-containing dendrimers of different generations (P(0), P(1) and P(2)), affords the triangular prismatic host guest compounds [P(n)subset of Ru(6)(p-cymene)(6)(tpt)(2)(donq)(3)](6+) ([P(n)subset of 1](6+)). The host-guest nature of these systems, with the pyrenyl moiety being encapsulated in the hydrophobic cavity of the cage and the dendritic functional group pointing outwards, was confirmed by NMR spectroscopy ((1)H, 2D and DOSY). The host-guest properties of these systems were studied in solution by NMR and UV/Vis spectroscopic methods, allowing the determination of their affinity constants (K(a)). Moreover, the ability of these water-soluble host-guest systems to carry the pyrenyl-containing dendrimers into cancer cells was evaluated on human ovarian cancer cells. The host-guest systems are all more cytotoxic than the empty cage [1][CF(3)SO(3)](6) (IC(50) approximate to 4 mu M), with the most active compound, [P(0)subset of 1][CF(3)SO(3)](6), being an order of magnitude more cytotoxic.
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