期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 17, 期 26, 页码 7271-7275出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201003005
关键词
biodegradability; drug delivery; hydrogen; metal-organic frameworks; nanoparticles
资金
- 973 project [2009CB930403]
- Grand New Drug Development Program of China [2009ZX09310-007]
The physical or chemical event that generally causes stimuli responses is limited to the formation or destruction of secondary forces, such as hydrogen bonding, hydrophobic effects, electrostatic interactions, and simple reactions. Here, pH-responsive behavior of metal-organic coordination bonding, which is intrinsic to natural systems (e.g., transferrin recycling in cells), is becoming a strong candidate for a new stimulus-responsive route. We have designed a simple pH-responsive release system by integrating a metal ion and ligand or self-assembling these species with biodegradable host molecules to form nanoparticles with metal-ligand or host-metal-ligand architectures. The cleavage of either or both the metal-ligand or the host-metal coordination bond in response to pH variations causes significant damage to the nanoparticles and the subsequent release of ligand molecules under designated pH conditions.
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