期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 17, 期 12, 页码 3398-3405出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201003148
关键词
asymmetric synthesis; crotylation; flow chemistry; homopropargylation; microreactors
资金
- AstraZeneca
- Alexander von Humboldt Foundation
- EPSRC
- Mitsubishi Tanabe Pharma
- Royal Society
- BP Endowment
- Engineering and Physical Sciences Research Council [EP/F069685/1] Funding Source: researchfish
- EPSRC [EP/F069685/1] Funding Source: UKRI
Diastereoselective chain-elongation reactions are important transformations for the assembly of complex molecular structures, such as those present in polyketide natural products. Here we report new methods for performing crotylation reactions and homopropargylation reactions by using newly developed low-temperature flow-chemistry technology. In-line purification protocols are described, as well as the application of the crotylation protocol in an automated multi-step sequence.
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