期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 17, 期 34, 页码 9395-9405出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201100527
关键词
cavitands; host-guest systems; hydrazones; molecular containers; nanocapsules
资金
- National Science Foundation [CHE-0518351, CHE-0957611]
- Rutgers University
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0957611] Funding Source: National Science Foundation
The thermodynamically controlled syntheses of different di-, tetra-, and hexacavitand polyacylhydrazone nanocapsules are reported. [2+4]-, [4+8]-, and [6+12]-nanocapsules assemble upon reacting a tetraformyl cavitand with two equivalents of isophthalic dihydrazide, or terephthalic dihydrazide in the presence of trifluoroacetic acid, whereby the building blocks are linked together through 8, 16, or 24 newly formed acylhydrazone bonds. Futhermore, the reaction of the tetraformylcavitands with different trigonal planar trihydrazides, simultaneously leads to the formation of [2+4]- and [6+8]-nanocapsules in varying ratios that depend on the cavitand to trihydrazide ratio and the nature of the cavitand and trihydrazide building blocks. The product ratios are rationalized with the different conformational strain of the acylhydrazone linkages in these nanocapsules. Diffusion NMR experiments with the hexacavitand polyacylhydrazone nanocapsules yield solvo-dynamic radii that range from 1.6 to 2.5 nm, consistent with estimates from force field calculations, and support, that these capsules have solvent filled, spherical interiors, the sizes of which approaches those of smaller proteins.
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