期刊
JOURNAL OF HEPATOLOGY
卷 62, 期 5, 页码 1068-1075出版社
ELSEVIER
DOI: 10.1016/j.jhep.2014.12.007
关键词
HVPG; Sonoelastography; Cirrhosis; Liver disease; Ultrasound
资金
- Instituto de Salud Carlos III (ISCiii, FEDER) [PI13/00341]
- Instituto de Salud Carlos III
- European Commission under the Seventh Framework Programme (FP7-PEOPLE-IAPP) [612273]
Background & Aims: Real-time shear wave elastography (RT-SWE) might be useful to assess the severity of portal hypertension; reliability criteria for measurement are needed. Methods: We prospectively included 88 consecutive patients undergoing hepatic venous pressure gradient measurement (HVPG, reference standard) for portal hypertension. Liver stiffness (LS) was measured by RT-SWE and by transient elastography (TE). Spleen stiffness (SS) was measured by RT-SWE. Reliability criteria for RT-SWE were searched, and the accuracy of these techniques to identify HVPG P10 mmHg (clinically significant portal hypertension, CSPH) was tested and internally validated by bootstrapping analysis. Results: LS and SS by RT-SWE were feasible respectively in 87 (99%) and 58 (66%) patients. Both correlated with HVPG (LS: R = 0.611, p < 0.0001 and SS: R = 0.514, p < 0.0001). LS performed well for diagnosing CSPH (optimism corrected AUROC = 0.858). Reliability of measurements was influenced by standard deviation (SD)/median ratio and depth. SD/median <= 0.10 and depth of measurement <5.6 cm were associated to 96.3% well classified for CSPH, while when one or none of the criteria were fulfilled the rates were 76.4% and 44.4%, respectively. Measurements fulfilling at least one criterion were considered acceptable; in these patients, RT-SWE performance to detect CSPH was excellent (AUROC = 0.939; 95% CI: 0.865-1.000; p < 0.0001; best cut-off: 15.4 kPa). LS by RT-SWE and by TE were strongly correlated (R = 0.795, p < 0.0001) and performed similarly both in per protocol and in intention-to-diagnose analysis after applying reliability criteria. Conclusions: LS by RT-SWE is an accurate method to diagnose CSPH if reliability criteria (SD/median <= 0.10 and/or depth <5.6 cm) are fulfilled. (C) 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据