期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 17, 期 17, 页码 4905-4913出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201002938
关键词
2-azapodophyllotoxin; Garner aldehyde; natural products; tetrahydroisoquinoline; total synthesis
资金
- National Research Foundation of Korea (NRF)
- Korean Ministry of Education, Science, and Technology (MEST)
- BK21 Program
We herein report a robust and efficient synthetic route to highly functionalized enantiopure 1,2,3,4-tetrahydroisoquinolines (THIQs) from Garner aldehyde. We utilized the inherent chirality of Garner aldehyde through 1,2- and 1,3-/1,4-asymmetric inductions iteratively to obtain 1,2,3,4-tetrasubstitued THIQs using rigid and isolable bridged oxazolidines without any external chiral sources. All possible stereoisomers of bridged oxazoliodines were efficiently synthesized from L- and D-Garner aldehydes and transformed into fully functionalized THIQs via diastereoselective ring opening with various nucleophiles in the presence of Yb(OTf)(3). This methodology furnished four out of eight possible diastereomers of 1,2,3,4-tetrasubstituted THIQs despite the electronic nature of substituents on the aryl rings. Finally, the enantioselective synthesis of 2-azapodophyllotoxin was achieved with an overall yield of 35.4% (eight steps) from D-Garner aldehyde using this synthetic route.
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