期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 17, 期 7, 页码 2089-2098出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201002149
关键词
DNA; groove binding.; luminescence; molecular recognition; ruthenium
资金
- EPSRC
- The British Council/DST (New Delhi)
The duplex-DNA binding properties of a nonintercalating polypyridyl ruthenium(II) complex that incorporates a linear extended ligand with a catechol moiety has been probed with a variety of photo- and biophysical techniques. These studies reveal that the complex groove binds to DNA sequences biphasically, and displays binding constants equivalent to those of high-affinity metallointercalators. The complex also displays preferential binding to AT-rich sequences. Changes in the structure of the coordinated catechol ligand and the incorporation of intercalating ancillary ligands into the complex were found to modulate both the optical-binding response and binding parameters of the system, which indicates that the catechol moiety plays a crucial role in the observed enhancement to binding affinities.
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