期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 17, 期 47, 页码 13240-13246出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201101817
关键词
annulation; asymmetric catalysis; azoles; heterocycles; one-pot reactions
资金
- OChemSchool
- Carlsberg Foundation
- FNU
- Foundation for Polish Science
This study demonstrates the first enantioselective synthesis of hydroxyalkyl- and aminoalkyl-substituted imidazoles, oxazoles, and thiazoles. The approach developed utilizes a highly effective one-pot reaction cascade that consists of either an organocatalytic epoxidation or aziridination of alpha,beta-unsaturated aldehydes coupled with a [3+2]-annulation, in which amidines, ureas, or thioureas act as effective 1,3-dinucleophilic species. The methodology described benefits from low catalyst loadings, commercially and readily available starting materials, and mild reaction conditions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据