期刊
JOURNAL OF HEPATOLOGY
卷 63, 期 6, 页码 1502-1510出版社
ELSEVIER
DOI: 10.1016/j.jhep.2015.08.001
关键词
Gut-liver axis; Gut dysbiosis; Nuclear receptor; Bile acid receptor; FXR; Probiotic; Prebiotic; Partial hepatectomy
资金
- National Institutes of Health [CA53596, DK092100, U01CA179582]
Studies examining the mechanisms by which the liver incurs injury and then regenerates usually focus on factors and pathways directly within the liver, neglecting the signaling derived from the gut-liver axis. The intestinal content is rich in microorganisms as well as metabolites generated from both the host and colonizing bacteria. Through the gut-liver axis, this complex soup exerts an immense impact on liver integrity and function. This review article summarizes data published in the past 30 years demonstrating the signaling derived from the gut-liver axis in relation to liver injury and regeneration. Due to the intricate networks of implicated pathways as well as scarcity of available mechanistic data, it seems that nutrigenomic, metabolomics, and microbiota profiling approaches are warranted to provide a better understanding regarding the interplay and impact between nutrition, bacteria, and host response in influencing liver function and healing. Therefore elucidating the possible molecular mechanisms that link microbiota alteration to host physiological response and vice versa. Published by Elsevier B.V. on behalf of the European Association for the Study of the Liver.
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