期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 16, 期 30, 页码 9117-9122出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201000568
关键词
alkylation; aromatic substitution; asymmetric catalysis; enones; fluorinated compounds
资金
- Ministerio de Ciencia e Innovacion
- FEDER [CTQ2006-14199, CTQ2009-13083]
- Generalitat Valenciana [ACOMP/2009/338]
Chiral complexes of BINOL-based ligands with zirconium tert-butoxide catalyze the Friedel-Crafts alkylation reaction of indoles with beta-trifluoromethyl-alpha,beta-unsaturated ketones to give functionalized indoles with an asymmetric tertiary carbon center attached to a trifluoromethyl group. The reaction can be applied to a large number of substituted alpha-trifluoromethyl enones and substituted indoles. The expected products were obtained with good yields and ees of up to 99%.
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