期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 16, 期 33, 页码 9944-9962出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201000741
关键词
cyclic compounds; cycloaddition; domino reactions; natural products; synthesis design
资金
- National Institutes of Health [CA 133002]
- Thailand Research Fund [PHD/0223/2548]
- Center for Petroleum, Petrochemistry and Advanced Materials
- National Science Foundation [CHE-9709183, CHE-0741968]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0741968] Funding Source: National Science Foundation
Natural products have been a great source of many small molecule drugs for various diseases. In spite of recent advances in biochemical engineering and fermentation technologies that allow us to explore microorganisms and the marine environment as alternative sources of drugs, more than 70% of the current small molecule therapeutics derive their structures from plants used in traditional medicine. Natural-product-based drug discovery relies heavily on advances made in the sciences of biology and chemistry. Whereas biology aims to investigate the mode of action of a natural product, chemistry aims to overcome challenges related to its supply, bioactivity, and target selectivity. This review summarizes the explorations of the caged Garcinia xanthones, a family of plant metabolites that possess a unique chemical structure, potent bioactivities, and a promising pharmacology for drug design and development.
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