期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 16, 期 32, 页码 9846-9854出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201001322
关键词
alcohols; alkynes; amines; gold; heterocycles
Different diyne-diols composed of two terminal homopropargylic alcohol groups were prepared by bi-directional synthesis Subjection of the syn diastereomers to NAC gold catalysts (NAC=nitrogen acyclic carbene) in the presence of external nucleophiles such as water or anilines provided substituted and highly rigid heterocyclic cages. The corresponding anti disastereomers polymerised An intermediate of the reactions of the syn diastereomers could be isolated and even be characterised by crystal structure analysis Overall, eight new bonds are formed in the reaction, which proceeds by a multistep sequence of highly selective hydroalkoxylations and hydrohydroxylation or hydroaminations For furyl substituents and for internal alkynes competing. reaction pathways could be identified. BY the cross-coupling of a product with an iodoaryl substituent, the use of these cage compounds as geometrically defined linking groups by using orthogonal transition-metal-catalysed methodology namely, gold and palladium catalysis, could be demonstrated
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据