期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 16, 期 34, 页码 10502-10506出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201000801
关键词
alkylation; domino reactions; imines; iridium; nitrogen heterocycles; palladium
资金
- MCINN of Spain [CTQ2008-04460]
- Bancaixa [P1.1B2007-04, P1.1B2008-16]
- Generalitat Valenciana
A new tandem catalytic process has been studied for a heterodimetallic complex containing both iridium and palladium fragments connected by a 1,2,4-trimethyltriazolyldiylidene ligand. The process implies the unprecedented preparation of imines from the direct reaction of nitroarenes and primary alcohols. The global process comprises the following steps: 1) reduction of the nitroarene to an amine, 2) oxidation of the alcohol to aldehyde, and 3) condensation of the aldehyde and the amine to form the corresponding imine. The oxidation of the alcohol to aldehyde is promoted by the iridium fragment, while the reduction of the nitro group to amine is facilitated by palladium. A wide set of different catalytic systems has been studied, showing that the Ir/Pd complex 1 is a highly active and stable catalyst in the preparation of imines.
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