期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 16, 期 32, 页码 9835-9845出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201000615
关键词
aza-Michael reaction; cross metathesis; sullinylamines; piperidines; pyrrolidines
N-Sulfinyl amines have been successfully employed as nitrogen nucleophiles for the asymmetric intramolecular aza-Michael reaction. The synthetic strategy involves a cross-metathesis reaction followed by the Michael-type cyclization. either in a base-catalyzed two-step procedure or in a tandem fashion The (developed methodology allows access to chiral substituted pyrrolidines and piperidines bearing one or two stereocenters and it has been applied to the synthesis of the piperidine alkaloid (-)-pinidinol
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