期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 16, 期 4, 页码 1319-1325出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200902153
关键词
cancer; carbohydrates; glycoconjugates; glycolipids; lipids
资金
- NIH [R01A95142]
- NATIONAL CANCER INSTITUTE [R01CA095142] Funding Source: NIH RePORTER
Monophosphoryl lipid A is a safe and potent immunostimulant and vaccine adjuvant, which is potentially useful for the development of effective carbohydrate-based conjugate vaccines. This paper presents a convergent and efficient synthesis of a monophosphoryl derivative of E. coli lipid A that has an alkyne functionality at the reducing end, which is suitable for coupling with various molecules. The coupling of this derivative to an N-modified analogue of tumor-associated antigen GM3 through click chemistry is also presented.
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