期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 16, 期 48, 页码 14479-14485出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201002205
关键词
alternarlactam; antifungal agents; antitumor agents; total synthesis
资金
- NSFC [30821006, 90813036]
- MOST [2007AA09Z446]
- CPSF [20100471313]
(-)-Alternarlactam [(-)-1], a new promising cytotoxin against two human cancer cell lines, was isolated from an endophyte culture and synthesized (along with (+)-1) from readily available starting materials. The absolute configuration, chirality-activity relevance and self-aggregation of (-)-1 were assigned by a combination of synthetic, spectroscopic and computational approaches. The full characterization of the new fungal cytotoxin may provide valuable information in the discovery of new antitumor agents.
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