期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 16, 期 47, 页码 14149-14158出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201000815
关键词
epoxidation; microreactors; organolithium compounds; stereoselectivity; synthetic methods
资金
- Grants-in-Aid for Scientific Research [21106002, 22750092] Funding Source: KAKEN
A flow microreactor system consisting of micromixers and microtubes provides an effective reactor for the generation and reactions of aryloxiranyllithiums without decomposition by virtue of short residence time and efficient temperature control. The deprotonation of styrene oxides with sBuLi can be conducted by using the flow microreactor system at -78 or 68 degrees C (whereas much lower temperatures (< -100 degrees C) are needed for the same reactions conducted under macrobatch conditions). The resulting alpha-aryloxiranyllithiums were allowed to react with electrophiles in the flow microreactor system at the same temperature. The sequential introduction of various electrophiles onto 2,3-diphenyl-oxiranes was also achieved by using an integrated flow microreactor, which serves as a powerful system for the stereoselective synthesis of tetrasubstituted epoxides.
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