期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 16, 期 21, 页码 6176-6186出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200903502
关键词
bioscaffolding; chromophoric scaffolding; click chemistry; helical structures; polyisocyanides
资金
- Technology Foundation STW
- Council for the Chemical Sciences of the Netherlands Organization for Scientific Research
- Royal Academy for Arts and Sciences
- NanoNed
The straightforward syntheses of polyisocyanides containing the alanine-cysteine motif in their side chains have been achieved. Detailed characterization of the polymers revealed a well-defined and highly stable helical conformation of the polyimine backbone responsible for the formation of rodlike structures of over one hundred nanometers. The 4(1) helix is further stabilized by beta-sheet-like interactions between the peptide arms. As a result, the cysteine sulfur atoms are regularly aligned along the polymer axis, which provides a unique platform for the scaffolding of various entities by using versatile click-chemistry post-modification approaches. For instance. pyrene derivatives were introduced through thio-specific reactions involving either maleimide, iodoacetamide, or thioester groups, leading to arrays of stacked chromophores with excimer-like emission. A water-soluble cysteine-rich polyisocyanide was successfully biotinylated and coupled to streptavidin.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据