期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 16, 期 34, 页码 10553-10559出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201000807
关键词
copper; domino reactions; furans; nanoparticles; regioselective synthesis
资金
- National Natural Science Foundation of China [20625205, 20772034, 20932002]
- Ministry of Education of China [20090172110014]
The formation of carbon-carbon and carbon-oxygen bonds continues to be an active and challenging field of chemical research. Nanoparticle catalysis has attracted considerable attention owing to its environmentally benign and high activity toward the reactions. Herein, we described a novel and effective nano-Cu2O-catalyzed one-pot domino process for the regioselective synthesis of alpha-carbonyl furans. Various electron-deficient alkynes with 2-yn-1-ols underwent this process smoothly in moderate to good yields in the presence of air at atmospheric pressure. It is especially noteworthy that was formed in an extremely direct manner without tedious stepwise synthesis. Additionally, as all of the starting materials are readily available, this method may allow the synthesis of more complex alpha-carbonyl furans. An experiment to elucidate the mechanism suggested that the process involved a carbene intermediate.
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