期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 15, 期 9, 页码 2129-2139出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200802301
关键词
alkynes; cobalt; cycloaddition; Hiyama cross-coupling; pyridine
资金
- IUF
- Ministere de la Recherche
- CNRS
The first [2+2+2] cocyclizations between ynamides, nitriles. and alkynes are reported. They open a new access to unprecedented nitrogen-containing heterocycles of type 2-trimethylsilyl-3-aminopyridines. Such frameworks, which can be found in various compounds of biological interest, are very difficult to prepare by conventional methods. However. using [CpCo(C2H4)(2)] (Cp = cyclopentadienyl) as catalyst, the intramolecular cyclizations could be achieved in up to 100% yield. The presence of the trimethylsilyl group allowed a rare type of Hiyama cross-coupling: one of the silylated pyridines could be coupled with p-iodoanisole to give a new type of biaryl system.
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