期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 16, 期 3, 页码 956-963出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200902472
关键词
cyclization; fluorescence; gold catalysis; methyleneoxazolines; oxazoles; propargylic amides
资金
- European Union
- Fonds der Chemischen Industrie
The substrate scope, the mechanistic aspects of the gold-catalyzed oxazole synthesis, and substrates with different aliphatic, aromatic, and functional groups in the side chain were investigated. Even molecules with several propargyl amide groups could easily be converted, delivering di- and trioxazoles with interesting optical properties. Furthermore, the scope of the gold(I)-catalyzed alkylidene synthesis was investigated. Further functionalizations of these isolable intermediates of the oxazole synthesis were developed and chelate ligands can be obtained. The use of Barluenga's reagent offers a new and mild access to the synthetically valuable iodoalkylideneoxazoles from propargylic amides, this reagent being superior to other sources of halogens.
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