期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 15, 期 8, 页码 1830-1834出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200802304
关键词
asymmetric synthesis; cyclization; domino reactions; gold
资金
- National Natural Sciences Foundation of China [20602006]
- Department of Science and Technology of JLSDG [20080548, 20082212]
- Training Fund of NENU'S Scientific Innovation Project [NENU-STC07017, NENU-STB07007]
Single step: Fused bicyclic and bridged tricyclic ketals were synthesized in a single step from the reactions of easily available 4-acyl-1,6-diynes with H2O and alkanols (see scheme). The highly efficient AuCl3-catalyzed multicomponent domino reactions, involving five C-O bond formations, can proceed in a highly regio- and diastereoselective manner at room temperature under air and lead to structures of high molecular complexity from simple starting materials in an atom economic way.
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