期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 15, 期 14, 页码 3577-3584出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200802261
关键词
cell recognition imaging agents; lanthanides; luminescence; nanocomposites
资金
- National Natural Science Foundation of China [20501006, 20775017]
- National Natural Science Funds [20825101, NCET-06-0353]
- Shanghai Leading Academic Discipline [13108]
- Huo Yingdong Education Foundation [104012]
Uniform silica-coated NaYF4: 20 mol % Yb, 2 mol % Er nanocomposites with good dispersibility, containing organic dye incorporated in the silica shell and folic acid conjugated oil the surface of the shell, were prepared and characterized. The core-shell nanocomposites are 20-22 nml in size, water soluble, and buffer stable, with good photostability and biocompatibility. Folic acid (FA) offers a means of targeting human cells that greatly overexpress the folate receptor (FR). By the use of confocal microscopy and quantitative flow cytometry analysis, we demonstrate the receptor-mediated delivery of FA-conjugated nanocomposites targeting FR-positive cell lines, such as KB cells. The receptor-mediated targeting was confirmed by a comparison with the uptake of these nanocomposites in FR-negative cell lines, such as MCF-7. These results show that the silica-coated upconverting nanophosphor (UCNP) nanocomposites prepared by our strategy can potentially be useful as multimodal bioimaging agents.
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