期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 15, 期 44, 页码 12043-12049出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200900603
关键词
drug delivery; ibuprofen; organic-inorganic hybrid composites; silica materials; sol-gel processes
Pure and modified silica materials were synthesised by a sol-gel process and used as carrier for the controlled release of ibuprofen, selected as model drug. A one-step synthesis was optimised for the preparation of various silica-drug composites by using tetraethoxysilane and 3-aminopropyltriethoxysilane as precursors at different molar ratios. The presence of aminopropyl groups on the silica surface influences the drug-delivery rate leading to a high degree the desorption process controlled.
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