期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 15, 期 32, 页码 8037-8048出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200900185
关键词
foldamers; nanofibers; oxazolidin-2-ones; self-assembly; anti-parallel beta sheet
资金
- Ministero dell'Universita e della Ricerca Scientifica
- Universita di Bologna [SFB 610, HO 2346/1-3]
- Fondazione del Monte di Bologna e di Ravenna
A series of oligomers of the type Boc-(L-Phe-D-Oxd)(n)-OBn (Boc = tert-butoxycarbonyl; Oxd=4-methyl-5-carboxy oxazolidin-2-one-, Bn = benzyl) were prepared for n = 2-5. The shortest oligomer, Boc-(L-Phe-D-Oxd)(2)- OBn, aggregates and forms a fiber-like material with an anti-parallel beta-sheet structure in which the oligopeptide units are connected to each other by only one intermolecular hydrogen bond. The longer oligomers exhibit structural heterogeneity. They start to organize into secondary structures by the formation of intramolecular hydrogen bonds at the pentamer level. Microscopy and diffraction of file oligomers indicated a crystalline character for only the shorter ones.
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