期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 15, 期 40, 页码 10514-10532出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200901316
关键词
alkaloids; allylic amination; heterocycles; iridium; natural products; total synthesis
资金
- Studienstiftung des deutschen Volkes
A method for the stereoselective synthesis of 2,6-disubstituted piperidines has been developed that is based on the use of an intramolecular iridiurn-catalyzed allylic substitution as a configurational switch. The procedure allows the preparation of 2-vinyl-piperidines with enantiomeric excesses (ee) of greater than 99%. As applications, total syntheses of piperidine alkaloids have been elaborated, most often by using Ru-catalyzed cross-met a theses as a key step for introduction of a side chain. Asymmetric total syntheses of the prosopis alkaloids (+)-prosopinine, (+)-prosophylline, (+)-prosopine, and of the dendrobate alkaloid (+)-241D and its C6 epimer are described.
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