期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 14, 期 25, 页码 7648-7657出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200800623
关键词
asyrnmetric catalysis; chiral building blocks; desymmetrization; enantioselectivity; propanediol
资金
- National Science Foundation
- National Institutes of Health [GM-33049]
- Eli Lilly Company
- NIH division or Research Resources
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM033049] Funding Source: NIH RePORTER
The asymmetric acylation of meso-2-substituted-1,3-propanediols by using an amphoteric chiral dinuclear zinc catalyst is described. It is has been demonstrated that both 2-alkyl- and 2-aryl-1,3-propanediols can be desymmetrized in high yields and enantioselectivities by using the same family of ligands. Given that both antipodes of the chiral catalyst are available, both enantiomers of the desymmetrized product can be obtained from the same starting material. The synthetic utility of the desymmetrized products has been demonstrated by the synthesis of several chiral building blocks with high enantiomeric purities.
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