期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 14, 期 31, 页码 9697-9705出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200800920
关键词
ene reaction; kinetic isotope effects; reaction mechanisms; solvent effects; triazolinediones
资金
- Greek Secretariat of Research and Technology
- IRAKLITOS [2002]
- PITHAS - GORAS II [2005]
The influence of the solvent oil the triazolinedione-alkene ene reaction mechanism has been investigated. Both inter- and intramolecular kinetic isotope effects with tetramethylethylenes and 2.2.2-(trideuterio)methyl-7-methyl-2.6-octadiene-[D-3]-1.1.1 provide for the first time, strong evidence for chanocs in the mechanism of the reaction oil going from non-protic to polar protic solvents. In non-protic polar or apolar solvents, an aziridinium imide that equilibrates to an insignificantt extent with an open intermediate (a dipolar or a polarized biradical) is formed irreversibly in the first, rate-determining step of the reaction, which is followed by fast hydrogen abstraction. On the contrary, in polar protic solvents, hydrogen abstraction is rate limiting. allowing the main dipolar intermediate to equilibrate with its open intermediate(s) as well as with the starting reagents.
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