期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 15, 期 5, 页码 1205-1216出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200801879
关键词
allylic substitution; asymmetric catalysis; chiral ligands; cross-coupling; iridium
We describe herein the development of the first iridium-catalyzed allylic substitution using arylzine nucleophiles. High enantioselectivities were obtained from the reactions, which used commercially available Grignard reagents as the starting materials. This methodology was also shown to be compatible with halogen/metal exchange reactions. Its synthetic potential is demonstrated by its application towards the formal synthesis of (+)-sertraline.
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