期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 14, 期 21, 页码 6483-6489出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200800101
关键词
guanidinium; hydrogen bonds; mass spectrometry; post-translational methylation; solvent effects
Highly solvated methylated guanidinium ions ([Me(n)Guan(H2O)(m)](+); n=0-4 and 6; m=1-> 50), which model the various post-translationally methylated states of arginine, were generated in the electrospray ionization (ESI) source of an unmodified commercial tandem mass spectrometer. The dehydration processes of highly solvated [Me,Guan(H2O)(21)](+) ions were monitored by using energy-dependent ESI MS. These data, together with supporting calculations, provide a detailed picture of the interplay of methylation and hydration, and both the calculations and the experimental evidence suggest a specific structural basis for the observed effects. The ramifications for biochemical binding events that are controlled by the post-translational methylation of arginine to give dimethylarginines are discussed.
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