期刊
CHEMISTRY OF NATURAL COMPOUNDS
卷 48, 期 3, 页码 447-450出版社
SPRINGER
DOI: 10.1007/s10600-012-0270-9
关键词
antifungal; cyclic octapeptide; solid-phase synthesis; cyclization; deprotection; purification
资金
- National Natural Science Foundation of China [20902109]
The present study deals with the first total synthesis of a new antifungal cyclic octapeptide, tunicyclin D, cyclo[VNIPPWHG], where all the amino acids are L-configuration, by a two-step solid-phase/solution synthesis strategy. The linear octapeptide was assembled by a solid-phase peptide synthesis (SPPS) method. Subsequently cyclization and deprotection were achieved in solution with high efficiency and reproducibility. The final product was purified by preparative RP-HPLC, and its structure was identified by ESI-MS, (1) H NMR, (13) C NMR, and HR-QTOF-MS.
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