期刊
CHEMISTRY OF MATERIALS
卷 25, 期 15, 页码 3030-3037出版社
AMER CHEMICAL SOC
DOI: 10.1021/cm401115b
关键词
mesoporous materials; core shell; nanocarrier; galvanic replacement; photothermal trigger
资金
- NSFC [21101029, 21273041, 21210004]
- China National Key Basic Research Program (973 Project) [2013CB934101, 2013CB934104, 2012CB224805, 2010CB933901]
- Shanghai Rising-Star Program [12QA1400400]
- State Key Laboratory of Pollution Control and Resource Reuse Foundation [PCRRF12001]
- Key Subjects Innovative Talents Program of Fudan University
- NPST program by King Saud University [12-NAN2544-02]
In this work, we have successfully developed a novel multifunctional near-infrared (NIR)-stimulus controlled drug release system based on gold nanocages as photothermal cores, mesoporous silica shells as supporters to increase the anticancer drug loading and thermally responsive poly(N-isopropylacrylamide) (PNIPAM) as NIR-stimuli gatekeepers (Au-nanocage@mSiO(2)@ PNIPAM). The unique Au-nano-cage@mSiO(2) nanocarrier was elaborately fabricated by utilizing yolk-shell Ag-nanocube@mSiO(2) nanostructure as a template by means of spatially confined galvanic replacement. The Au nanocage cores can effectively absorb and convert light to heat upon irradiation with a NIR laser, resulting in the collapse of the PNIPAM shell covering the exterior of mesoporous silica, and exposes the pores of mesoporous silica shell, realizing the triggered release of entrapped DOX drugs. The in vitro studies have clearly demonstrated the feasibility and advantage of the novel nanocarriers for remote-controlled drug release systems.
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