期刊
CHEMISTRY OF MATERIALS
卷 25, 期 15, 页码 2976-2985出版社
AMER CHEMICAL SOC
DOI: 10.1021/cm4005618
关键词
quantum dots; micelle; silica; core/shell; targeted bioimaging
资金
- Joint Initiative by Biomedical Research Council (BMRC) & Science and Engineering Research Council (SERC), Agency for Science, Technology and Research (A*Star, Singapore) [1121480002]
- SERC [1121202013]
CdSe/CdS/ZnS quantum dots (QDs) have been successfully encapsulated into poly(ethylene oxide) (PEO)-based polymeric micelle/silica dual layers via interfacial templating condensation. The encapsulation follows a green and straightforward microemulsion mechanism that directly proceeds in a near-neutral pH aqueous environment. No detriment to the optical properties of QDs is observed during encapsulation. The core shell nanoparticles generated possess a polymeric micelle framework with a single QD encapsulated in the hydrophobic micellar core, an ultrathin (<5 nm in thickness) yet robust silica shell confined to the micellar core/corona interface and free PEO chains dangling on the surface. The free PEO chains effectively prevent nonspecific adsorption of biomolecules to the nanoparticles. Double shielding of polymeric micelle/silica shell remarkably improves the fluorescence resistance of QDs to strong acids and highly salted buffers. In vitro testing using MDA-MB-231 breast cancer cells demonstrates that these organic/inorganic dual layer-protected QDs conjugated with folate show noncytotoxicity and bright fluorescence cellular imaging with high target specificity.
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