期刊
CHEMISTRY OF MATERIALS
卷 25, 期 13, 页码 2597-2602出版社
AMER CHEMICAL SOC
DOI: 10.1021/cm400700g
关键词
hybrid nanoparticles; core-shell; redox-responsive; PLGA-silica; controlled release
资金
- CICYT of Spain [CSD2009-00050, MAT2012-39290-C02-02]
- Spanish Ministerio de Economia y Competitividad [AP2008-02851]
A novel type of hybrid material based on a PLGA nanoparticle core and a redox-responsive amorphous organosilica shell have been successfully synthesized. The outer layer is obtained by self-assembly of silicate ions with a silsesquioxane containing a disulfide bridge. These organic linkers work as molecular gates that can be selectively cleaved by reducing agents. This system is particularly suitable for storage and release of hydrophobic molecules, as the treatment with dithiothreitol leaves open doors that allow for the discharge of encapsulated molecules in the organic matrix. Using pyrene as a probe molecule, it has been shown that after partial disruption of the organic inorganic coating, the release mechanism from PLGA particles fits pretty well into Higuchi's model, corresponding to a diffusion mediated process. These nanohybrids impose a better control and slower release of encapsulated molecules than bare PLGA nanoparticles, are reasonably stable in a physiological medium, and show great potential as stimuli-responsive vehicles for drug delivery.
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