期刊
CHEMISTRY OF MATERIALS
卷 24, 期 5, 页码 840-853出版社
AMER CHEMICAL SOC
DOI: 10.1021/cm2031569
关键词
polymer-drug conjugates; polymer therapeutics; polymeric prodrugs; nanomedicine; bioconjugation; drug delivery
资金
- National Institutes of Health [R01 EB007171, R01 EB007470]
- Utah Science Technology and Research (USTAR) initiative
The field of polymer therapeutics has evolved over the past decade and has resulted in the development of polymer-drug conjugates with a wide variety of architectures and chemical properties. Whereas traditional nondegradable polymeric carriers such as poly(ethylene glycol) (PEG) and N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers have been translated to use in the clinic, functionalized polymer-drug conjugates are increasingly being utilized to obtain biodegradable, stimuli-sensitive, and targeted systems in an attempt to further enhance localized drug delivery and ease of elimination. In addition, the study of conjugates bearing both therapeutic and diagnostic agents has resulted in multifunctional carriers with the potential to both see and treat patients. In this paper, the rational design of polymer-drug conjugates will be discussed, followed by a review of different classes of conjugates currently under investigation. The design and chemistry used for the synthesis of various conjugates will be presented with additional comments on their potential applications and current developmental status.
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