期刊
CHEMISTRY OF MATERIALS
卷 24, 期 15, 页码 3029-3037出版社
AMER CHEMICAL SOC
DOI: 10.1021/cm3015594
关键词
CuInS2/ZnS; quantum dots; micelles; in vitro imaging; in vivo imaging
资金
- National Natural Science Foundation of China [30800257, 30970776, 31050110123, 81071194]
- Natural Science Foundation of Jiangsu Province [BK2011634]
- Fundamental Research Funds for the Central Universities [JKP2011017]
The exploration of biocompatible quantum dots (QDs) for biomedical imaging is currently one of the fastest growing fields of nanotechnology. This strategy overcomes the intrinsic toxicity of well-developed II-VI and other semiconductor Us (Cd, Hg, Pb, Se, Te, As, etc.) that remains a major obstacle to their clinical use. In this report, we synthesized high-quality CuInS2/ZnS (CIS/ZnS) QDs without using conventional toxic heavy metals. These QDs exhibited improved photoluminescence (PL) properties, with tunable emission peaks ranging from 550 to 800 nm and a maximum PL quantum yield (QY) up to 80%. Next, we explored the effective loading of the prepared oil-soluble CIS/ZnS QDs using biodegradable folate-modified N-succinyl-N'-octyl chitosan (FA-SOC) micelles. Targeting efficacy of the resulting Us-loaded micelles to tumors using in vitro and in vivo optical imaging techniques was also investigated. The results show that the micelle platform allowed successful formulation of these oil-soluble QDs in water, while retaining the morphology, crystal structure, and PL of the initial CIS/ZnS QDs. This study demonstrates the versatility of using biocompatible CIS/ZnS QDs across different spatial scales (in vitro cell imaging and in vivo small animal imaging) for multicolor biological imaging applications.
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