期刊
CHEMISTRY OF MATERIALS
卷 23, 期 14, 页码 3318-3324出版社
AMER CHEMICAL SOC
DOI: 10.1021/cm200414c
关键词
manganese oxide; nanoplates; pi-pi interactions; magnetic resonance imaging; contrast agent
资金
- Korean Ministry of Education, Science and Technology through National Creative Research Initiative [R16-2002-003-01001-0]
- World Class University of National Research Foundation (NRF) of Korea [R31-10013]
- [2010-0029138]
Lamellar structured ultrathin manganese oxide nanoplates have been synthesized from thermal decomposition of manganese(II) acetylacetonate in the presence of 2,3-dihydroxynaphthalene, which promoted two-dimensional (2-D) growth by acting not only as a strongly binding surfactant but also as a structure-directing agent. Ultrathin manganese oxide nanoplates with a thickness of about 1 rim were assembled into a lamellar structure, and the width of the nanoplates could be controlled from 8 to 70 nm by using various coordinating solvents. X-ray absorption near-edge structure (XANES) spectra at the Mn K edge clearly showed that the nanoplates are mainly composed of Mn(II) species with octahedral symmetry. These hydrophobic manganese oxide nanoplates were ligand-exchanged with amine-terminated poly(ethyleneglycol) to generate water-dispersible nanoplates and applied to T1 contrast agents for magnetic resonance imaging (MRI). They exhibited a very high longitudinal relaxivity (r(1)) value of up to 5.5 mM(-1)s(-1) derived from their high concentration of manganese ions exposed on the surface, and strong contrast enhancement of in vitro and in vivo MR images was observed with a very low dose.
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