期刊
CHEMISTRY OF MATERIALS
卷 22, 期 6, 页码 1966-1976出版社
AMER CHEMICAL SOC
DOI: 10.1021/cm903357q
关键词
-
资金
- U.S. Agency for International Development
- U.S.-Pakistan Science and Technology Cooperative Program [PGA-P280422]
- National Science Foundation [CHE 0316078]
Multifunctional nanoparticles that Call provide long circulation and specific accumulation, illuminate the targeted object, and intelligently dose the pathological zones will enable major advancements in diagnosis and therapy. To facilitate a simultaneous tumour-cell imaging and adequate local delivery to the tumor site, we develop core-shell structured hybrid nanogels (40-80 nm) composed of a Ag nanoparticle (NP) as core and smart gel of poly(N-isopropylacrylamide-co-acrylic acid) as shell. The pH-induced shrinkage of the nanogel increases the UV-vis absorption intensity and causes I blue shift Of the surface plasmon bands of the Ag NP core. The smart nanogel call overcome cellular barriers to enter the intracellular region and light LIP the Mouse melanoma B16F10 cells, Including the nuclear regions. The surface property and concentrations of and the hybrid nanogels influences their interactions with cells, resulting in different cell morphology and selective cell staining. The pH-responsive hybrid nanogels exhibit not Only a high drug loading capacity but also a pH-controllable drug releasing behavior. Smart hybrid nanogels with optical and therapeutic functionality, designed by integration of functional building blocks, offer broad opportunities For biomedical applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据