期刊
CHEMISTRY OF HETEROCYCLIC COMPOUNDS
卷 49, 期 12, 页码 1723-1731出版社
SPRINGER
DOI: 10.1007/s10593-014-1424-4
关键词
3-formylchromone; pyranopyrones; antimicrobial activity; enzyme inhibitors; Knoevenagel-Cope reaction; pharmacophore; urease inhibitory
资金
- Research Center, College of Pharmacy and Deanship of Scientific Research, King Saud University
- Ministry of Higher Education of Malaysia [UM.C/HIR/MOHE/SC/12]
The synthesis and antimicrobial evaluation of a series of chromone-linked substituted heterocyclic derivatives is described. The condensation of 3-formylchromone with acetoacetamide under Knoevenagel-Cope reaction conditions was also explored, and the condensation with 4-hydroxy-6-methyl-2H-pyran-2-one constitutes a facile route to pyranopyrone fused systems. Most of the compounds exhibit good antimicrobial properties.
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