4-HYDROXY-2-QUINOLONES 144. ALKYL-, ARYLALKYL-, AND ARYLAMIDES OF 2-HYDROXY-4-OXO-4H-PYRIDO[1,2-a]PYRIMIDINE-3-CARBOXYLIC ACID AND THEIR DIURETIC PROPERTIES

Alkyl-, arylalkyl-, and arylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid were prepared with a view to establishing a structure-biological activity relationship. A comparative analysis has been made of their diuretic properties and those of the structurally similar 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamides.