期刊
CHEMISTRY LETTERS
卷 43, 期 1, 页码 20-25出版社
CHEMICAL SOC JAPAN
DOI: 10.1246/cl.130965
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资金
- NIGMS NIH HHS [R01 GM097225, R01 GM042569] Funding Source: Medline
CsoR/Rcra transcriptional repressors adopt a disc-shaped, all a-helical dimer of dimers tetrameric architecture, with a four-helix bundle the key structural feature of the dimer. Individual members of this large family of repressors coordinate Cu(I) or Ni(II)/Co(II) or perform cysteine sulfur chemistry in mitigating the effects of metal or metabolite toxicity, respectively. Here we highlight recent insights into the functional diversity of this fascinating family of repressors.
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