4.3 Article

Formal anti-Markovnikov Hydroamination of Terminal Aryl Alkynes with Pinacolborane and Hydroxylamines via Zr/Cu Sequential Catalysis

期刊

CHEMISTRY LETTERS
卷 42, 期 10, 页码 1128-1130

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CHEMICAL SOC JAPAN
DOI: 10.1246/cl.130485

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资金

  1. Ministry of Education, Culture, Sports, Science and Technology, Japan
  2. Uehara Memorial Foundation
  3. Grants-in-Aid for Scientific Research [25620084] Funding Source: KAKEN

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We have developed sequential Zr/Cu catalysis involving regioselective hydroboration and electrophilic amination for the formal anti-Markovnikov hydroamination of terminal aryl alkynes. The reaction system can provide a facile access to enamines from terminal acetylenes with high regioselectivity under mild conditions.

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