期刊
CHEMISTRY LETTERS
卷 41, 期 7, 页码 728-729出版社
CHEMICAL SOC JAPAN
DOI: 10.1246/cl.2012.728
关键词
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资金
- [16GS0206]
- [21221009]
- Grants-in-Aid for Scientific Research [21221009] Funding Source: KAKEN
We screened a colored clone from a metagenomic library derived from the marine sponge Halichondria okadai. We isolated a yellow pigment, halichrome A (1), which was structurally elucidated to be a biindole, exhibited cytotoxicity against B16 melanoma cells and was substituted with an ethyl group. To the best of our knowledge, this is the first report of the isolation of a novel compound from a metagenomic library derived from a marine sponge.
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