Synthesis and chiral recognition or novel regioselectively substituted amylose derivatives

Two novel amylose derivatives 1a and 1b bearing different substituents at 2-, 3-, and 6-positions of a glucose ring have been successfully synthesized, and their abilities of enantiomer resolution in high-performance liquid chromatography (HPLC) have been evaluated. These derivatives exhibited the ability comparable or better to the commercial amylose-based column, Chiralpak AD.