A Molecularly Imprinted Polymer for the Reconstruction of a Molecular Recognition Region

Cofactor-binding protein mimics were prepared by metalloporphyrin-based covalent molecular imprinting of amino acid derivatives, where an apo-type scaffold was obtained by removing the template and the porphyrin moieties from the resulting, polymer after the imprinting process, and when the porphyrin derivative was incorporated as the cofactor to yield the holo-type binding sites, enantioselectivity was induced and the chirality of the target amino acids was recognized.